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KMID : 0525720000050020074
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Journal of Chitin and Chitosan
2000 Volume.5 No. 2 p.74 ~ p.78
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Chitosan - oligosaccharides Inhibits HL-60 Cell Growth through Induction of Apoptosis
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정용욱/Jeong YW
김기성/오재영/박종천/이제철/유광재/김정우/장석종/백원기/서성일/서민호/조재위/Kim KS/Oh JY/Park JC/Lee JC/Yoo KJ/Kim JW/Chang SJ/Baek WK/Suh SI/Suh MH/Cho JW
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Abstract
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Chitosan-oligosaccharides (OCHT) have been suggested that it has an inhibitory effect on cancer cell growth. However, the precise mechanism remains to be elucidated. Recently, apoptosis has been recognized that it plays a key role in protection of cancer development. To elucidate the mechanism underlying inhibition of cancer cell growth by OCHT, it is necessary to determine whether the OCHT inhibit the growth of HL-60 cells (human promyelocytic leukemia cell line) through apoptosis. The growth rates of HL-60 cells were remarkably decreased after OCHT treatment. The induction of apoptotic DNA fragmentation by adding OCHT were occurred in a dose dependent fashion. In apoptotic HL-60 cells, caspase-3 activation and Bcl-2 protein down-regulation were shown. Thug, our data suggest that OCHT may inhibit the growth of HL-60 cells through induction of apoptosis.
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